INDEX, VOLUME 14, 2023

Volume 14 contents, author and keyword index

Dmd053322 2018..2023

In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...

Abstracts Volume 14 Number 4

The main goal of the paper is to present how CAD and the simulation results of a virtual model were used to develop and adapt an educational platform to various manufacturing scenarios in an Industrial Logistics laboratory optimizing the performances in terms of productivity. Our paper is divided in two parts. The first part describes the design and development of an educational platform contai...

Dmd059675 2023..2032

Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...

Dev104240 2014..2023

Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...